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YM 298198 hydrochloride

2448 1 Citation Datasheet / COA / SDS
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YM 298198 hydrochloride | CAS No. 1216398-09-2 | Group I mGluR Antagonists
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Description: Highly potent, selective non-competitive mGlu1 antagonist

Chemical Name: 6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

Non-competitive antagonist with high affinity and selectivity for mGlu1 receptors (Ki = 19 nM); inactive at other mGlu receptor subtypes (mGlu2-7), ionotropic receptors and glutamate transporters (IC50 > 10 μM). Inhibits glutamate-induced IP production more potently than CPCCOEt (IC50 values are 16 nM and 6.3 μM respectively), and is orally active in vivo, demonstrating an antinociceptive effect in hyperalgesic mice.

Desmethyl Derivative also available.

Technical Data

M.Wt:
378.92
Formula:
C18H22N4OS.HCl
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
1216398-09-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Astellas Pharma Inc.
Other Product-Specific Information:

Product Datasheets

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Citation for YM 298198 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for YM 298198 hydrochloride include:

1 Citation: Showing 1 - 1

  1. Drebrin Isoforms Critically Regulate NMDAR- and mGluR-Dependent LTD Induction.
    Authors: Yasuda Et al.
    Front Cell Neurosci  2018;12:330

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Tocris Small Molecules

Desmethyl-YM 298198

2447
1 Image

VersaClone cDNA Plasmids

Human mGluR1 (AAB05337) VersaClone cDNA

RDC0983

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