YM 298198 hydrochloride
Chemical Name: 6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride
Purity: ≥99%
Biological Activity
Non-competitive antagonist with high affinity and selectivity for mGlu1 receptors (Ki = 19 nM); inactive at other mGlu receptor subtypes (mGlu2-7), ionotropic receptors and glutamate transporters (IC50 > 10 μM). Inhibits glutamate-induced IP production more potently than CPCCOEt (IC50 values are 16 nM and 6.3 μM respectively), and is orally active in vivo, demonstrating an antinociceptive effect in hyperalgesic mice.Desmethyl Derivative also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
-
The protective signaling of metabotropic glutamate receptor 1 is mediated by sustained, β-arrestin-1-dependent ERK phosphorylation.
Emery et al.
J.Biol.Chem., 2010;285:26041 -
Radioligand binding properties and pharmacological characterization of 6-Amino-N-cyclohexyl-N,3-dimethyl-thiazolo[3,2-a]-benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective and noncompetitive antagonist of metabo
Kohara et al.
J.Pharmacol.Exp.Ther., 2005;315:163
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for YM 298198 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for YM 298198 hydrochloride include:
1 Citation: Showing 1 - 1
-
Drebrin Isoforms Critically Regulate NMDAR- and mGluR-Dependent LTD Induction.
Authors: Yasuda Et al.
Front Cell Neurosci 2018;12:330
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsTocris Small Molecules
VersaClone cDNA Plasmids
Reviews for YM 298198 hydrochloride
There are currently no reviews for this product. Be the first to review YM 298198 hydrochloride and earn rewards!
Have you used YM 298198 hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image