Z-DEVD-FMK Caspase-3 Inhibitor

Name: Z-DEVD-FMK Caspase-3 Inhibitor
Brand: Tocris Bioscience
SKU: 8009
Price: 442 USD
Availability: InStock

Tocris Bioscience | Catalog # 8009

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Product Documents

Caspase-3 Inhibitor

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Caspase-3 Inhibitor

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Product Description

Z-DEVD-FMK Caspase-3 Inhibitor is a cell-permeable, irreversible inhibitor of caspase-3/CPP32. It inhibits tumor cell apoptosis. In vivo, it has a neuroprotective effect in rat hippocampus following seizures. It also significantly reduces post-traumatic apoptosis, and improved neurological recovery, before and after induced traumatic brain injury in rat.

Product Specifications for Z-DEVD-FMK Caspase-3 Inhibitor

Molecular Weight

668.67

Formula

C₃₀H₄₁FN₄O₁₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

634911-78-7

InChI Key

GBJVAVGBSGRRKN-OXMHKTTFSA-N

SMILES

[H]N(C(OCC1=CC=CC=C1)=O)[C@H](C(N[C@H](C(N[C@H](C(NC(C(CF)=O)CC(OC)=O)=O)C(C)C)=O)CCC(OC)=O)=O)CC(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in DMSO

Calculators

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Background References

References are publications that support the biological activity of the product.

Yakovlev Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J.Neurosci. 1997 PMID: 9295387
Henshall Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. J.Neurochem. 2000 PMID: 10693954
Kugawa Apoptosis of NG108-15 cells induced by Bupren. hydrochloride occurs via the caspase-3 pathway. Biol.Pharm.Bull. 2000 PMID: 10963298
Brocksted Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. J.Biol.Chem. 1998 PMID: 9774422

Product Documents for Z-DEVD-FMK Caspase-3 Inhibitor

Certificate of Analysis

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Product Specific Notices for Z-DEVD-FMK Caspase-3 Inhibitor

For research use only

Related Research Areas

Cysteine Proteases and Regulators

NOD-like Receptors and the Inflammasome

Citations for Z-DEVD-FMK Caspase-3 Inhibitor

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