Z-VAD-FMK

Tocris Bioscience | Catalog # 2163

Cell-permeable, irreversible caspase inhibitor
Tocris Bioscience

Key Product Details

Description

Cell-permeable, irreversible caspase inhibitor
View all Inflammasomes Inhibitors »

Product Description

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.

Product Specifications for Z-VAD-FMK

Molecular Weight

467.49

Formula

C22H30FN3O7

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone

CAS Number

634911-81-2

PubChem ID

5497174

InChI Key

MIFGOLAMNLSLGH-SXUUOERCSA-N

SMILES

[H]N(C(OCC1=CC=CC=C1)=O)[C@H](C(N[C@H](C(NC(C(CF)=O)CC(OC)=O)=O)C)=O)C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 9.35mg/ml in DMSO

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 136 publications citing the usage of this product.

Product Documents for Z-VAD-FMK

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Z-VAD-FMK

For research use only

Customer Reviews for Z-VAD-FMK (3)

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  • Used for FACS
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: phagocyte
    Verified Customer | Posted 06/06/2020
    25 μM
    Z-VAD-FMK 2163
  • It blocks caspases activity in cultured microglia
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Verified Customer | Posted 09/27/2019
    We pretreated to cultured microglia to inhibit caspases activity at 20microM
  • Caspase inhibitor
    Name: Paramananda Saikia
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: AML12
    Verified Customer | Posted 01/04/2018
    12.5 micro molar concentration was used in the study.
    AML12 hepatocytes were cultured and were per-treated with Z-VAD-FMK.

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