Z-VAD-FMK

  ( 20 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:2163
Chemical Name:Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
Product Details
Citations (20)
Reviews
Biological Activity
Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
Technical Data
  • M.Wt:
    467.49
  • Formula:
    C22H30FN3O7
  • Sequence:
    VAD

    (Modifications: Val-1 = Z-Val, Asp-3 = (OMe)-fluoromethylketone)

  • Solubility:
    Soluble to 9.35 mg/ml in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
    187389-52-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Z-VAD-FMK include:

20 Citations: Showing 1 - 10
Filter your results:

  1. Methylsulfonylmethane Induces p53 Independent Apoptosis in HCT-116 Colon Cancer Cells
    Authors: Karabay Et al.
    International Journal of Molecular Sciences  2016;17:1123
  2. The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.
    Authors: Baron Et al.
    Mol Cell Biol  2015;6:e1629
  3. NF-κB signaling is required for XBP1 (unspliced and spliced)-mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancer.
    Authors: Hu Et al.
    Clin Cancer Res  2015;35:379
  4. Sorafenib induces cathepsin B-mediated apoptosis of bladder cancer cells by regulating the Akt/PTEN pathway. The Akt inhibitor, perifosine, enhances the sorafenib-induced cytotoxicity against bladder cancer cells.
    Authors: Amantini Et al.
    Cell Death Dis  2015;2:395
  5. Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation.
    Authors: Bonnefond Et al.
    Oncoscience  2015;20:535
  6. A delay prior to mitotic entry triggers caspase 8-dependent cell death in p53-deficient Hela and HCT-116 cells.
    Authors: Silva Et al.
    Apoptosis  2015;14:1070
  7. mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation.
    Authors: Moon Et al.
    Cell Rep  2015;12:102
  8. Parasympathetic innervation regulates tubulogenesis in the developing salivary gland.
    Authors: Nedvetsky Et al.
    Dev Cell  2014;30:449
  9. A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells.
    Authors: Hight Et al.
    Evid Based Complement Alternat Med  2014;20:2126
  10. The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells.
    Authors: Sagher Et al.
    Cancer Cell Int  2014;14:75
  11. Role of ROS and HMGB1 in contact allergen-induced IL-18 production in human keratinocytes.
    Authors: Galbiati Et al.
    J Invest Dermatol  2014;134:2719
  12. The mTORC2 component rictor contributes to cisplatin resistance in human ovarian cancer cells.
    Authors: Im-aram Et al.
    PLoS One  2013;8:e75455
  13. A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells.
    Authors: Kim Et al.
    Cell Death Dis  2013;4:e750
  14. A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.
    Authors: Jahchan Et al.
    Cancer Discov  2013;3:1364
  15. Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro.
    Authors: Wang Et al.
    Mar Drugs  2013;2013:857929
  16. Cytotoxic effect of clerosterol isolated from Codium fragile on A2058 human melanoma cells.
    Authors: Kim Et al.
    Mol Cancer Res  2013;11:418
  17. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.
    Authors: Sullivan Et al.
    Cell Cycle  2012;8:646
  18. Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness.
    Authors: Cook Et al.
    Oncotarget  2012;72:3337
  19. Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking.
    Authors: Woo Et al.
    J Biol Chem  2012;287:3963
  20. Glioma regression in vitro and in vivo by a suicide combined treatment.
    Authors: García-Escudero Et al.
    Cancer Res  2008;6:407
Expand to show all Citations

FAQs

No product specific FAQs exist for this product, however you may

View all Peptide FAQs
Average Rating: 5 (Based on 1 review)

Have you used Z-VAD-FMK?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Read what people are saying who have used Z-VAD-FMK.

We have 1 review tested in 1 species: Mouse.

Filter by Ratings
Excellent
(1)
All Ratings
Filter by Applications
All Applications
Filter by Species
Mouse
(1)
All Species

Images Ratings Applications Species Reviewed By Date Details
  Excellent
  Mouse Paramananda Saikia 01/04/2018
Show

Summary

Species Mouse

Other Experimental Details

Other Experimental Details 12.5 micro molar concentration was used in the study.

Please scroll the above reviews for more
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee