Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro
= 0.0015 - 5.8 mM). Active in vivo
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Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32.
Slee et al.
ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-α.
Kunstle et al.
Inhibition of human caspases by peptide-based and macromolecular inhibitors.
Garcia-Calvo et al.
Processing/activation of caspases, -3 and -7 and -8 but not caspase-2, in the induction of apoptosis in B-chronic lyphocytic leukemia cells.
King et al.
The citations listed below are publications that use Tocris products. Selected citations for Z-VAD-FMK include:
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