Zacopride hydrochloride

Key Product Details

Product Description

Zacopride hydrochloride is a highly potent 5-HT₃ receptor antagonist (K_i = 0.38 nM) and 5-HT₄ receptor agonist (K_i = 373 nM). Antiemetic and anxiolytic following systemic administration in vivo.

Product Specifications for Zacopride hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Zacopride hydrochloride

The following data is based on the product molecular weight 346.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.89 mL	14.44 mL	28.88 mL
5 mM	0.58 mL	2.89 mL	5.78 mL
10 mM	0.29 mL	1.44 mL	2.89 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Nagakura Pharmacological properties of a novel gastrointestinal prokinetic benzamide selective for human 5-HT₄ receptor versus human 5-HT₃ receptor. Pharmacol.Res. 1999 PMID: 10328995
• Costall Zacopride: anxiolytic profile in rodent and primate models of anxiety. J.Pharm.Pharmacol. 1988 PMID: 2900320
• Kii and Ito Effects of 5-HT₄-receptor agonists, cisapride, mosapride citrate, and zacopride, on cardiac action potentials in guinea pig isolated papillary muscles. J.Cardiovasc.Pharmacol. 1997 PMID: 9213211
• Cohen Comparison of the 5-HT₃ receptor antagonist properties of ICS 205-930, GR38032F and zacopride. J.Pharmacol.Exp.Ther. 1989 PMID: 2521513

Product Documents for Zacopride hydrochloride