Zacopride hydrochloride (CAS 101303-98-4): R&D Systems
Catalog Number: 1795
Chemical Name: (±)-4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamide hydrochloride
Biological Activity
Highly potent 5-HT3 receptor antagonist (Ki = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). Antiemetic and anxiolytic following systemic administration in vivo.
Technical Data
  • M.Wt:
    346.26
  • Formula:
    C15H20ClN3O2.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    101303-98-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of 5-HT4-receptor agonists, cisapride, mosapride citrate, and zacopride, on cardiac action potentials in guinea pig isolated papillary muscles.
    Kii and Ito
    J.Cardiovasc.Pharmacol., 1997;29:670
  2. Comparison of the 5-HT3 receptor antagonist properties of ICS 205-930, GR38032F and zacopride.
    Cohen et al.
    J.Pharmacol.Exp.Ther., 1989;248:197
  3. Pharmacological properties of a novel gastrointestinal prokinetic benzamide selective for human 5-HT4 receptor versus human 5-HT3 receptor.
    Nagakura et al.
    Pharmacol.Res., 1999;39:375
  4. Zacopride: anxiolytic profile in rodent and primate models of anxiety.
    Costall et al.
    J.Pharm.Pharmacol., 1988;40:302
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Zacopride hydrochloride include:

3 Citations: Showing 1 - 3
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  1. 5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functionally regulated mitochondrialfunctions
    Authors: Wang Et al.
    Scientific Reports 2016;6:37336
  2. Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms.
    Authors: Otvos Et al.
    Circulation 2015;7:2336
  3. The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors.
    Authors: Ding Et al.
    Toxins (Basel) 2015;29:725

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