Chemical Name: (±)-4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamide hydrochloride
Biological ActivityZacopride hydrochloride is a highly potent 5-HT3 receptor antagonist (Ki = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). Antiemetic and anxiolytic following systemic administration in vivo.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Comparison of the 5-HT3 receptor antagonist properties of ICS 205-930, GR38032F and zacopride.
Cohen et al.
Zacopride: anxiolytic profile in rodent and primate models of anxiety.
Costall et al.
Effects of 5-HT4-receptor agonists, cisapride, mosapride citrate, and zacopride, on cardiac action potentials in guinea pig isolated papillary muscles.
Kii and Ito
Pharmacological properties of a novel gastrointestinal prokinetic benzamide selective for human 5-HT4 receptor versus human 5-HT3 receptor.
Nagakura et al.
Citations for Zacopride hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Zacopride hydrochloride include:
3 Citations: Showing 1 - 3
5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functionally regulated mitochondrialfunctions
Authors: Wang Et al.
Scientific Reports 2016;6:37336
Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms.
Authors: Otvos Et al.
The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors.
Authors: Ding Et al.
Toxins (Basel) 2015;29:725
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