ZD 7155 hydrochloride
Chemical Name: 5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride
Biological ActivityZD 7155 hydrochloride is a potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. Displaces [125I]-angiotensin II binding with an IC50 value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT1 antagonist, losartan.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Zeneca ZD7155: a novel, potent and orally-effective angiotensin II receptor antagonist.
Oldham et al.
Endogenous angiotensin II and the reflex response to stimulation of cardiopulmonary serotonin 5HT3 receptors.
Veelken et al.
Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and los. in the rat.
Junggren et al.
Citations for ZD 7155 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for ZD 7155 hydrochloride include:
2 Citations: Showing 1 - 2
Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress.
Authors: Nostramo Et al.
Proc Natl Acad Sci U S A 2012;215:291
Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect.
Authors: Leite-Moreira Et al.
Br J Pharmacol 2006;147:690
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