Catalog Number: 1211
Chemical Name: 5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride
Biological Activity
A potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. Displaces [125I]-angiotensin II binding with an IC50 value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT1 antagonist, losartan.
Technical Data
  • M.Wt:
    474.99
  • Formula:
    C26H26N6O.HCl
  • Solubility:
    Soluble to 10 mM in water with gentle warming
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    146709-78-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Background References
  1. Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and losartan in the rat.
    Junggren et al.
    J.Pharm.Pharmacol., 1996;48:829
  2. Endogenous angiotensin II and the reflex response to stimulation of cardiopulmonary serotonin 5HT3 receptors.
    Veelken et al.
    Br.J.Pharmacol., 1998;125:1761
  3. Zeneca ZD7155: a novel, potent and orally-effective angiotensin II receptor antagonist.
    Oldham et al.
    Br.J.Pharmacol., 1993;109:P136
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ZD 7155 hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress.
    Authors: Nostramo Et al.
    Proc Natl Acad Sci U S A 2012;215:291
  2. Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect.
    Authors: Leite-Moreira Et al.
    Br J Pharmacol 2006;147:690

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