A potent and selective competitive antagonist for the angiotensin II type 1 (AT1
) receptor. Displaces [125
I]-angiotensin II binding with an IC50
value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT1
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Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and losartan in the rat.
Junggren et al.
Endogenous angiotensin II and the reflex response to stimulation of cardiopulmonary serotonin 5HT3 receptors.
Veelken et al.
Zeneca ZD7155: a novel, potent and orally-effective angiotensin II receptor antagonist.
Oldham et al.
The citations listed below are publications that use Tocris products. Selected citations for ZD 7155 hydrochloride include:
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