Zileuton

Catalog # Availability Size / Price Qty
3308/10
3308/50
Zileuton | CAS No. 111406-87-2 | Lipoxygenase Inhibitors
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Description: 5-LOX inhibitor; orally bioavailable
Alternative Names: ICI D2138

Chemical Name: N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea

Purity: ≥99%

Product Details
Citations (7)
Reviews

Biological Activity

Orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB4 synthesis (IC50 values are 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively). Inhibits antigen-induced contraction of tracheal strips in vitro (IC50 = 6 μM) and exhibits antiasthmatic activity in vivo. Also weakly inhibits CYP1A2 (Ki = 66 - 98 μM).

Technical Data

M.Wt:
236.29
Formula:
C11H12N2O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
111406-87-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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⚠ WARNING: This product can expose you to chemicals including Zileuton, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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