Zileuton

  ( 4 citations )    
Product Datasheet
Catalog Number:3308
Alternate Names:ICI D2138
Chemical Name:N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea
Product Details
Citations (4)
Reviews
Biological Activity
Orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB4 synthesis (IC50 values are 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively). Inhibits antigen-induced contraction of tracheal strips in vitro (IC50 = 6 μM) and exhibits antiasthmatic activity in vivo. Also weakly inhibits CYP1A2 (Ki = 66 - 98 μM).
Technical Data
  • M.Wt:
    236.29
  • Formula:
    C11H12N2O2S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    111406-87-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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