Zileuton

Key Product Details

Product Description

Zileuton is an orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB₄ synthesis (IC₅₀ values are 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively). Inhibits antigen-induced contraction of tracheal strips in vitro (IC₅₀ = 6 μM) and exhibits antiasthmatic activity in vivo. Also weakly inhibits CYP1A2 (K_i = 66 - 98 μM). Ferroptosis inhibitor.

Product Specifications for Zileuton

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Zileuton

The following data is based on the product molecular weight 236.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.23 mL	21.16 mL	42.32 mL
5 mM	0.85 mL	4.23 mL	8.46 mL
10 mM	0.42 mL	2.12 mL	4.23 mL
50 mM	0.08 mL	0.42 mL	0.85 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 21 publications citing the usage of this product.

• Xie Ferroptosis: process and function. Cell Death Differ. 2016 PMID: 26794443
• Malo The 5-lipoxygenase inhibitory activity of zil. in in vitro and in vivo models of antigen-induced airway anaphylaxis. Pulm.Pharmacol. 1994 PMID: 8081074
• Lu Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. Drug Metab.Dispos. 2003 PMID: 14570767
• McMillan Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase. Br.J.Pharmacol. 1992 PMID: 1334748

Product Documents for Zileuton