Catalog Number: 2345
Alternate Names: MPQX
Chemical Name: [[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]phosphonic acid
Biological Activity
Competitive AMPA/kainate antagonist. In rat cortical membranes, displays high affinity for [3H]-AMPA (Ki = 120 nM) and [3H]-CNQX (Ki = 32 nM) binding sites and low affinity for kainate and NMDA channel-associated binding sites (IC50 values range from 2.5 to 11 μM). Inhibits currents induced by AMPA, kainate and NMDA with IC50 values of 21 nM, 27 nM, and > 1 μM respectively. Displays anxiolytic, anticonvulsant and muscle relaxant activity in vivo.
Technical Data
  • M.Wt:
    409.25
  • Formula:
    C14H15N3O6F3P
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    161605-73-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Novel α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor antagonists of 2,3-benzodiazepine type: chemical synthesis, in vitro characterization, and in vivo prevention of acute neurodegeneration.
    Elger et al.
    J.Med.Chem., 2005;48:4618
  2. X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor.
    Sobolevsky
    Nature, 2009;462:745
  3. ZK200775: a phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauman
    Turski et al.
    Proc.Natl.Acad.Sci.USA., 1998;95:10960
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ZK 200775 include:

1 Citations: Showing 1 - 1

  1. Akt-dependent expression of NAIP-1 protects neurons against amyloid-{beta} toxicity.
    Authors: Lesne Et al.
    J Biol Chem 2005;280:24941

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