Catalog # Availability Size / Price Qty
(S)-AMPA | CAS No. 83643-88-3 | AMPA Receptor Agonists
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Description: Selective AMPA agonist; active isomer of (RS)-AMPA (Cat. No. 0169)

Chemical Name: (S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

Purity: ≥99%

Product Details
Citations (13)
Supplemental Products

Biological Activity

(S)-AMPA is an active enantiomer of AMPA (EC50 = 3.5 μM).

NPEC-caged-(S)-AMPA, Inactive Enantiomer and Racemate also available.

Technical Data

Soluble to 50 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for (S)-AMPA

The citations listed below are publications that use Tocris products. Selected citations for (S)-AMPA include:

13 Citations: Showing 1 - 10

  1. Serotonergic mechanisms involved in antidepressant-like responses evoked by GLT-1 blockade in rat infralimbic cortex.
    Authors: Gasull-Camôs
    Neuropharmacology  ;139:41
  2. Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.
    Authors: Wagner Et al.
    Cell Rep  2019;28:11
  3. The Retromer Supports AMPA Receptor Trafficking During LTP.
    Authors: Temkin Et al.
    Neuron  2017;94:74
  4. Kynurenic Acid Induces Impairment of Oligodendrocyte Viability: On the Role of Glutamatergic Mechanisms.
    Authors: Langner Et al.
    Neurochem Res  2017;42:838
  5. Involvement of AMPA Receptor and Its Flip and Flop Isoforms in Retinal Ganglion Cell Death Following Oxygen/Glucose Deprivation.
    Authors: Park Et al.
    Invest Ophthalmol Vis Sci  2016;57:508
  6. Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2.
    Authors: Bell Et al.
    PLoS One  2015;6:7066
  7. Membrane potential measurements of isolated neurons using a voltage-sensitive dye.
    Authors: Fairless Et al.
    PLoS One  2013;8:e58260
  8. Physiological release of endogenous tau is stimulated by neuronal activity.
    Authors: Pooler Et al.
    J Neurosci  2013;14:389
  9. Overexpression of calcium-permeable glutamate receptors in glioblastoma derived brain tumor initiating cells.
    Authors: Oh Et al.
    EMBO Rep  2012;7:e47846
  10. Activity-dependent ubiquitination of the AMPA receptor subunit GluA2.
    Authors: Lussier Et al.
    Proc Natl Acad Sci U S A  2011;31:3077


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