Potent, selective and competitive benzodiazepine receptor antagonist (IC50
values are 0.4 and 0.7 nM for inhibition of [3
H]-flunitrazepam binding to rat cerebellum and hippocampus respectively). Similar in vivo
profile to flumazenil
(Ro 15-1788, Cat No. 1328); produces anxiogenic effects in some behavioral tests and anxiolytic effects in others. Orally active.
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All Tocris products are intended for laboratory research use only.
Evaluation of the β-carboline ZK 93 426 as a benzodiazepine receptor antagonist.
Jensen et al.
Enhancement of γ-aminobutyric acid binding by the anxiolytic β-carbolines ZK 93423 and ZK 91296.
Corda et al.
Effects of β-carbolines in animal models of anxiety.
File and Baldwin
Brain Res.Bull., 1987;19:293