ZK 93426 hydrochloride

Key Product Details

Product Description

ZK 93426 hydrochloride is a potent, selective and competitive benzodiazepine receptor antagonist (IC₅₀ values are 0.4 and 0.7 nM for inhibition of [³H]-flunitrazepam binding to rat cerebellum and hippocampus respectively). Similar in vivo profile to flumazenil (Ro 15-1788, Cat No. 1328); produces anxiogenic effects in some behavioral tests and anxiolytic effects in others. Orally active.

Product Specifications for ZK 93426 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ZK 93426 hydrochloride

The following data is based on the product molecular weight 348.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.87 mL	14.33 mL	28.67 mL
5 mM	0.57 mL	2.87 mL	5.73 mL
10 mM	0.29 mL	1.43 mL	2.87 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Corda Enhancement of γ-aminobutyric acid binding by the anxiolytic β-carbolines ZK 93423 and ZK 91296. J.Neurochem. 1987 PMID: 2881979
• File and Baldwin Effects of β-carbolines in animal models of anxiety. Brain Res.Bull. 1987 PMID: 3315125
• Jensen Evaluation of the β-carboline ZK 93 426 as a benzodiazepine receptor antagonist. Psychopharmacology 1984 PMID: 6089247

Product Documents for ZK 93426 hydrochloride