ZK 93426 hydrochloride
Chemical Name: 4-Methyl-5-(1-methylethoxy)-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester hydrochloride
Biological ActivityZK 93426 hydrochloride is a potent, selective and competitive benzodiazepine receptor antagonist (IC50 values are 0.4 and 0.7 nM for inhibition of [3H]-flunitrazepam binding to rat cerebellum and hippocampus respectively). Similar in vivo profile to flumazenil (Ro 15-1788, Cat No. 1328); produces anxiogenic effects in some behavioral tests and anxiolytic effects in others. Orally active.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Evaluation of the β-carboline ZK 93 426 as a benzodiazepine receptor antagonist.
Jensen et al.
Enhancement of γ-aminobutyric acid binding by the anxiolytic β-carbolines ZK 93423 and ZK 91296.
Corda et al.
Effects of β-carbolines in animal models of anxiety.
File and Baldwin
Brain Res.Bull., 1987;19:293
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