Potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3). pIC50
values are 7.1, 5.6, 4.4, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Breaks down in neutral buffer (t½
= 36 mins, pH 7.43, 25°C) to form ZM 449829
(Cat. No. 1366).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold with the permission of AstraZeneca Ltd.
Naphthyl ketones: a new class of janus kinase 3 inhibitors.
Brown et al.
The citations listed below are publications that use Tocris products. Selected citations for ZM 39923 hydrochloride include:
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