ZM 39923 hydrochloride
Chemical Name: 3-benzylisopropylamino-1-naphthalen-2-yl-propan-1-one hydrochloride
Biological ActivityZM 39923 hydrochloride is a potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3). pIC50 values are 7.1, 5.6, 4.4, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Breaks down in neutral buffer (t½ = 36 mins, pH 7.43, 25°C) to form ZM 449829 (Cat. No. 1366).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Naphthyl ketones: a new class of janus kinase 3 inhibitors.
Brown et al.
Citations for ZM 39923 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for ZM 39923 hydrochloride include:
3 Citations: Showing 1 - 3
Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
Authors: Rogers and Gahring
NBHA reduces acrolein-induced changes in ARPE-19 cells: possible involvement of TGFβ.
Authors: Vidro-Kotchan Et al.
Curr Eye Res 2011;36:370
A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors.
Authors: Schaertl Et al.
J Biomol Screen 2010;15:478
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