Catalog Number: 1367
Chemical Name: 3-benzylisopropylamino-1-naphthalen-2-yl-propan-1-one hydrochloride
Biological Activity
Potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3). pIC50 values are 7.1, 5.6, 4.4, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Breaks down in neutral buffer (t½ = 36 mins, pH 7.43, 25°C) to form ZM 449829 (Cat. No. 1366).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca Ltd.
Background References
  1. Naphthyl ketones: a new class of janus kinase 3 inhibitors.
    Brown et al.
    Bioorg.Med.Chem.Lett., 2000;10:575

The citations listed below are publications that use Tocris products. Selected citations for ZM 39923 hydrochloride include:

Showing Results 1 - 2 of 2

  1. Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
    Authors: Rogers and Gahring
  2. A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors.
    Authors: Schaertl Et al.
    J Biomol Screen
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