ZM 39923 hydrochloride

Catalog # Availability Size / Price Qty
1367/10
1367/50

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ZM 39923 hydrochloride | CAS No. 1021868-92-7 | JAK Kinase Inhibitors
1 Image
Description: Potent, selective JAK3 inhibitor

Chemical Name: 3-benzylisopropylamino-1-naphthalen-2-yl-propan-1-one hydrochloride

Purity: ≥99%

Product Details
Citations (3)
Reviews

Biological Activity

ZM 39923 hydrochloride is a potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3). pIC50 values are 7.1, 5.6, 4.4, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Breaks down in neutral buffer (t½ = 36 mins, pH 7.43, 25°C) to form ZM 449829 (Cat. No. 1366).

Technical Data

M.Wt:
367.92
Formula:
C23H25NO.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
1021868-92-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of AstraZeneca Ltd.

Background References

  1. Naphthyl ketones: a new class of janus kinase 3 inhibitors.
    Brown et al.
    Bioorg.Med.Chem.Lett., 2000;10:575

Product Datasheets

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Citations for ZM 39923 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for ZM 39923 hydrochloride include:

3 Citations: Showing 1 - 3

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