ZNL 02-096

Tocris Bioscience | Catalog # 7240

Potent and selective Wee1 Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Potent and selective Wee1 Degrader (PROTAC®)
View all Active Degraders »

Product Description

ZNL 02-096 is a potent and selective Wee1 Degrader (PROTAC®) that comprises the Wee1 inhibitor AZD 1775 joined by a linker to the cereblon-binding ligand Pomalidomide (Cat. No. 6302). ZNL 02-096 selectively degrades Wee1 at submicromolar concentrations, while sparing PLK1, an AZD 1775 secondary target. In MOLT-4 cells in vitro, ZNL 02-096 induces degradation of Wee1, accumulation of DNA damage, arrest of the cell cycle in the G2/M phase and apoptosis. The compound shows antiproliferative effects in a panel of 300 cancer cell lines.

Wee1 antibody validated for Western Blot also available: Catalog # NBP1-33506.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

Product Specifications for ZNL 02-096

Molecular Weight

799.89

Formula

C42H45N11O6

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-((3-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

CAS Number

2414418-49-6

PubChem ID

153555373

InChI Key

LZUDSNUROXNVPH-UHFFFAOYSA-N

SMILES

CC(O)(C1=NC(N2N(C(C3=CN=C(N=C23)NC4=CC=C(N5CCN(CC5)CCCNC6=C7C(N(C(C7=CC=C6)=O)C8CCC(NC8=O)=O)=O)C=C4)=O)CC=C)=CC=C1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.99 50

Preparing Stock Solutions for ZNL 02-096

The following data is based on the product molecular weight 799.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.50 mL 12.50 mL 25.00 mL
2.5 mM 0.50 mL 2.50 mL 5.00 mL
5 mM 0.25 mL 1.25 mL 2.50 mL
25 mM 0.05 mL 0.25 mL 0.50 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for ZNL 02-096

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ZNL 02-096

For research use only

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