ZXH 3-26

Tocris Bioscience | Catalog # 6713

Potent and selective BRD4 Degrader (PROTAC®)
Tocris Bioscience
Discontinued Product
6713 has been discontinued. View all Active Degraders products.

Key Product Details

Description

Potent and selective BRD4 Degrader (PROTAC®)
View all Active Degraders »

Product Description

ZXH 3-26 is a potent and selective BRD4 Degrader (PROTAC®) (DC50 ~ 5 nM). Exhibits no significant degradation of BRD2 and BRD3. Whole proteome mass spectometry shows significant downregulation of BRD4 only. Active intracellularly.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

Product Specifications for ZXH 3-26

Molecular Weight

785.27

Formula

C38H37ClN8O7S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

Methyl (6S)-4-(4-chlorophenyl)-2-[[[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentyl]amino]carbonyl]-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetate

CAS Number

2243076-67-5

PubChem ID

132427808

InChI Key

OTKOFICOCDRNDA-PMCHYTPCSA-N

SMILES

COC(C[C@@H]1N=C(C2=CC=C(C=C2)Cl)C3=C(N4C(C)=NN=C14)SC(C(NCCCCCNC5=C6C(N(C(C6=CC=C5)=O)C7CCC(NC7=O)=O)=O)=O)=C3C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 78.53 100

Preparing Stock Solutions for ZXH 3-26

The following data is based on the product molecular weight 785.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.27 mL 6.37 mL 12.73 mL
5 mM 0.25 mL 1.27 mL 2.55 mL
10 mM 0.13 mL 0.64 mL 1.27 mL
50 mM 0.03 mL 0.13 mL 0.25 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for ZXH 3-26

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ZXH 3-26

For research use only

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