ZXH 3-26

Catalog # Availability Size / Price Qty
6713/5
ZXH 3-26 | CAS No. 2243076-67-5 | Active Degraders
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Description: Potent and selective BRD4 degrader

Chemical Name: Methyl (6S)-4-(4-chlorophenyl)-2-[[[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentyl]amino]carbonyl]-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetate

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective BRD4 degrader (DC50 ~ 5 nM). Exhibits no significant degradation of BRD2 and BRD3. Whole proteome mass spectometry shows significant downregulation of BRD4 only. Active intracellularly.

Technical Data

M.Wt:
785.27
Formula:
C38H37ClN8O7S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2243076-67-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute.

Background References

  1. Plasticity in binding confers selectivity in ligand-induced protein degradation.
    Nowak et al.
    Nat.Chem.Biol., 2018;14:706

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