ZXH 3-26

Catalog # Availability Size / Price Qty
ZXH 3-26 | CAS No. 2243076-67-5 | Active Degraders
1 Image
Description: Potent and selective BRD4 Degrader (PROTAC®)

Chemical Name: Methyl (6S)-4-(4-chlorophenyl)-2-[[[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentyl]amino]carbonyl]-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetate

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

ZXH 3-26 is a potent and selective BRD4 Degrader (PROTAC®) (DC50 ~ 5 nM). Exhibits no significant degradation of BRD2 and BRD3. Whole proteome mass spectometry shows significant downregulation of BRD4 only. Active intracellularly.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute.

Background References

  1. Plasticity in binding confers selectivity in ligand-induced protein degradation.
    Nowak et al.
    Nat.Chem.Biol., 2018;14:706

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for ZXH 3-26

The citations listed below are publications that use Tocris products. Selected citations for ZXH 3-26 include:

1 Citation: Showing 1 - 1


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for ZXH 3-26

There are currently no reviews for this product. Be the first to review ZXH 3-26 and earn rewards!

Have you used ZXH 3-26?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.