Signaling Pathways in Mouse Th17 Differentiation

Signaling Pathways in Mouse Th17 Differentiation

IL-17-producing T helper cells (Th17) are a recently described lineage of CD4⁺ effector T cells that are distinct from the Th1 and Th2 CD4⁺ lineages. In mice, TGF-beta and IL-6 induce signaling pathways that promote the differentiation of Th17 cells by STAT3^-, and ROR gamma t-dependent transcription. Characterizing the factors required for Th17 lineage commitment and amplification is critical to our understanding of how adaptive immune responses are orchestrated.

Related Information

Human CD Marker Products

IL-17 Family

IL-17 is Produced by T-cells

Mini-review: Interleukin 17 (IL-17)

Recent Citations: R&D Systems Products for Th17-related Research

Technical Note: IL-17 Family Antibodies for Flow Cytometry

Th17 Cells

Th17 Differentiation: An Evolving Target for Multiple Sclerosis Therapy