Apelin Receptor Antagonists

The apelin receptor comprises 380 amino acids and exhibits homology with the angiotensin II type 1 receptor (AT₁), although it does not bind angiotensin. No apelin receptor subtypes have been discovered to date. In humans, APJ receptors are expressed in endothelial cells and cardiomyocytes, and throughout the brain and spinal cord. In the periphery the highest expression levels are seen in the spleen and placenta, while lower levels of expression are seen in other tissues. APJ receptors are ...