ML 221

Catalog # Availability Size / Price Qty
4748/10
4748/50
Cat.No. 4748 - ML 221 | C17H11N3O6S | CAS No. 877636-42-5
1 Image
Description: Apelin receptor (APJ) antagonist

Chemical Name: 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one

Product Details
Supplemental Products
Reviews

Biological Activity

Apelin receptor (APJ) antagonist (IC50 values are 0.70 and 1.75 μM in a cAMP assay and β-arrestin assay, respectively). Displays >37-fold selectivity over the closely related angiotensin II type 1 (AT1) receptor. Exhibits no toxicity towards human hepatocytes at concentrations >50 μM.

Technical Data

Formula:
C17H11N3O6S
Solubility:
Soluble to 10 mM in DMSO
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
877636-42-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Product Datasheets

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for ML 221

There are currently no reviews for this product. Be the first to review ML 221 and earn rewards!

Have you used ML 221?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.