Potent apelin receptor antagonist (Ki
= 82 nM; IC50
= 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13
on forskolin-induced cAMP accumulation in CHO-K1-APJ cells.
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All Tocris products are intended for laboratory research use only.
Discovery of a competitive apelin receptor (APJ) antagonist.
Macaluso et al.