AZ 5704

Catalog # Availability Size / Price Qty
6330/5
6330/25
Cat.No. 6330 - AZ 5704 | C23H23FN6O2 | CAS No. 1941214-06-7
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Description: Potent and selective ATM kinase inhibitor; orally bioavailable

Chemical Name: 7-Fluoro-6-[6-(methoxymethyl)-3-pyridinyl]-4-[[(1S)-1-(1-methyl-1H-pyrazol-3-yl)ethyl]amino]-3-quinolinecarboxamide

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective ATM kinase inhibitor (IC50 = 0.6 nM in an enzyme inhibition assay). Exhibits > 600-fold selectivity for ATM over other kinases. Inhibits ATM kinase in an in vitro cellular assay (IC50 = 0.33 μM). Potentiates the antitumor effects of the topoisomerase 1 inhibitor irinotecan (CPT 11, Cat. No. 2688) in tumor bearing, immunocompromised mice. Orally bioavailable.

Technical Data

M.Wt:
434.47
Formula:
C23H23FN6O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1941214-06-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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