KU 55933

Catalog # Availability Size / Price Qty
3544/10
KU 55933 | CAS No. 587871-26-9 | ATM and ATR Kinase Inhibitors
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Description: Potent and selective ATM kinase inhibitor

Chemical Name: 2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one

Purity: ≥98%

Product Details
Citations (77)
Reviews

Biological Activity

Potent, selective and competitive ATM kinase inhibitor (Ki = 2.2 nM, IC50 values are 13, 2500, 9300, 16600, > 100000 and > 100000 nM at ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively). Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1 levels in vitro. Acts as a radio- and chemosensitizer for the treatment of cancer.

Technical Data

M.Wt:
395.49
Formula:
C21H17NO3S2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
587871-26-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for KU 55933

The citations listed below are publications that use Tocris products. Selected citations for KU 55933 include:

77 Citations: Showing 1 - 10

  1. Osteogenic differentiation of skeletal muscle progenitor cells is activated by the DNA damage response.
    Authors: Rosina Et al.
    Sci Rep  2019;9:5447
  2. Protein Phosphatase 1 Regulatory Subunit SDS22 Inhibits Breast Cancer Cell Tumorigenesis by Functioning as a Negative Regulator of the AKT Signaling Pathway.
    Authors: Paul Et al.
    Neoplasia  2019;21:30
  3. Cytotoxic and Antitumor Activity of Lactaptin in Combination with Autophagy Inducers and Inhibitors.
    Authors: Bagamanshina Et al.
    Biomed Res Int  2019;2019:4087160
  4. Autophagy is required for lung development and morphogenesis.
    Authors: Yeganeh Et al.
    J Clin Invest  2019;130:2904
  5. ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.
    Authors: Balmus Et al.
    Nat Commun  2019;10:87
  6. Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection.
    Authors: Ibler Et al.
    Nat Commun  2019;10:4040
  7. The CHD6 chromatin remodeler is an oxidative DNA damage response factor.
    Authors: Moore Et al.
    Nat Commun  2019;10:241
  8. The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication.
    Authors: Edwards Et al.
    J Virol  2018;92
  9. Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice.
    Authors: Bhatia Et al.
    F1000Res  2018;7:1233
  10. The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage.
    Authors: Piquet Et al.
    Mol Cell  2018;72:888
  11. The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination.
    Authors: Delgado-Benito Et al.
    Mol Cell  2018;72:636
  12. Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders.
    Authors: Calo Et al.
    Nature  2018;554:112
  13. Cell type-dependent bimodal p53 activation engenders a dynamic mechanism of chemoresistance.
    Authors: Yang Et al.
    Sci Adv  2018;4:eaat5077
  14. SETD2-dependent H3K36me3 plays a critical role in epigenetic regulation of the HPV31 life cycle.
    Authors: Gautam Et al.
    PLoS Pathog  2018;14:e1007367
  15. Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy.
    Authors: Benkafadar Et al.
    EMBO Mol Med  2017;9:7
  16. ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration.
    Authors: Jaiswal Et al.
    EMBO J  2017;36:2161
  17. NOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy.
    Authors: Wu Et al.
    Cell Death Differ  2017;24:1632
  18. Drug-induced hyperploidy stimulates an antitumor NK cell response mediated by NKG2D and DNAM-1 receptors.
    Authors: Acebes-Huerta Et al.
    Oncoimmunology  2016;5:e1074378
  19. A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis.
    Authors: Lambrus Et al.
    J Cell Biol  2016;214:143
  20. Fe65 Is Phosphorylated on Ser289 after UV-Induced DNA Damage.
    Authors: Langlands Et al.
    PLoS One  2016;11:e0155056
  21. Activation of DNA Damage Response Pathways during Lytic Replication of KSHV.
    Authors: Hollingworth Et al.
    Mol Cell Biol  2015;7:2908
  22. Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells.
    Authors: Ahmed Et al.
    Cancer Res  2015;75:4416
  23. A radiosensitivity MiRNA signature validated by the TCGA database for head and neck squamous cell carcinomas.
    Authors: Liu Et al.
    Aging Cell  2015;6:34649
  24. DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation.
    Authors: Allen Et al.
    Front Oncol  2015;5:260
  25. Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins.
    Authors: Colin Et al.
    Viruses  2015;5:140156
  26. The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.
    Authors: Stechow Et al.
    Proc Natl Acad Sci U S A  2015;35:1254
  27. Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related.
    Authors: Beggs Et al.
    Toxicology  2015;331:35
  28. Spatio-temporal regulation of RAG2 following genotoxic stress.
    Authors: Rodgers Et al.
    DNA Repair (Amst)  2015;27:19
  29. Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage.
    Authors: Gibbs-Seymour Et al.
    Open Biol  2015;14:162
  30. Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells.
    Authors: Teng Et al.
    Gynecol Oncol  2015;136:554
  31. F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress.
    Authors: Malonia Et al.
    J Cell Biol  2015;112:8632
  32. Contrasting Effects of the Cytotoxic Anticancer Drug gemcit. and the EGFR Tyrosine Kinase Inhibitor gefi. on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells.
    Authors: Okita Et al.
    PLoS One  2015;10:e0139809
  33. TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence.
    Authors: Ye Et al.
    EMBO Mol Med  2014;6:1294
  34. SMAR1 coordinates HDAC6-induced deacetylation of Ku70 and dictates cell fate upon irradiation.
    Authors: Chaudhary Et al.
    Cell Death Dis  2014;5:e1447
  35. ATM specifically mediates repair of double-strand breaks with blocked DNA ends.
    Authors: Alvarez-Quilón Et al.
    Nat Commun  2014;5:3347
  36. Inhibition of ataxia telangiectasia mutated (ATM) kinase suppresses herpes simplex virus type 1 (HSV-1) keratitis.
    Authors: Alekseev Et al.
    Invest Ophthalmol Vis Sci  2014;55:706
  37. Defying DNA double-strand break-induced death during prophase I meiosis by temporal TAp63α phosphorylation regulation in developing mouse oocytes.
    Authors: Kim and Suh
    Mol Cell Biol  2014;34:1460
  38. The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair.
    Authors: Henriksson Et al.
    Genes Dev  2014;28:2726
  39. Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation.
    Authors: Wu Et al.
    J Biol Chem  2014;289:34378
  40. Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons.
    Authors: Sheng Et al.
    Oncotarget  2014;289:20845
  41. Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication.
    Authors: Sakai Et al.
    Cell Cycle  2014;13:1015
  42. SMC1-mediated intra-S-phase arrest facilitates bocavirus DNA replication.
    Authors: Luo Et al.
    J Virol  2013;87:4017
  43. Human papillomavirus episome stability is reduced by aphidicolin and controlled by DNA damage response pathways.
    Authors: Edwards Et al.
    J Virol  2013;87:3979
  44. Targeting XRCC1 deficiency in breast cancer for personalized therapy.
    Authors: Sultana Et al.
    Cancer Res  2013;73:1621
  45. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
    Authors: Montané and Menand
    Nat Chem Biol  2013;64:4361
  46. Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.
    Authors: Yüce and West
    Mol Cell Biol  2013;33:406
  47. Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination.
    Authors: Lee Et al.
    PLoS One  2013;33:3568
  48. Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.
    Authors: Bothmer Et al.
    Chembiochem  2013;210:115
  49. Hairpin-end conformation of adeno-associated virus genome determines interactions with DNA-repair pathways.
    Authors: Cataldi and McCarty
    J Biol Chem  2013;20:686
  50. Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells.
    Authors: Passaro Et al.
    Endocr Relat Cancer  2013;20:633
  51. A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair.
    Authors: Britton Et al.
    J Cell Biol  2013;202:579
  52. E1a promotes c-Myc-dependent replicative stress: implications in glioblastoma radiosensitization.
    Authors: Valero Et al.
    Cell Cycle  2013;13:52
  53. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway.
    Authors: Fard Et al.
    Cell Cycle  2013;13:408
  54. Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining.
    Authors: Oksenych Et al.
    J Biol Chem  2013;110:2234
  55. Role of 53BP1 oligomerization in regulating double-strand break repair.
    Authors: Lottersberger Et al.
    Proc Natl Acad Sci U S A  2013;110:2146
  56. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.
    Authors: Sullivan Et al.
    Proc Natl Acad Sci U S A  2012;8:646
  57. Mechanism-based screen establishes signalling framework for DNA damage-associated G1 checkpoint response.
    Authors: Richardson Et al.
    PLoS One  2012;7:e31627
  58. PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling.
    Authors: Ando Et al.
    Mol Cell  2012;47:681
  59. SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response.
    Authors: Mund Et al.
    Nucleic Acids Res  2012;40:11363
  60. Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates γ-histone 2AX (γ-H2AX) levels upon ionizing radiation.
    Authors: Neumayer Et al.
    J Biol Chem  2012;287:42206
  61. Regulation of SIRT1 activity by genotoxic stress.
    Authors: Yuan Et al.
    Genes Dev  2012;26:791
  62. Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice.
    Authors: Yamamoto Et al.
    J Virol  2012;198:305
  63. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation.
    Authors: Fumagalli Et al.
    Nat Cell Biol  2012;14:355
  64. Detection of early Abl kinase activation after ionizing radiation by using a peptide biosensor.
    Authors: Tang Et al.
    Mol Cell Biol  2012;13:665
  65. Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors.
    Authors: Sultana Et al.
    Int J Cancer  2012;131:2433
  66. Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation.
    Authors: Klotz-Noack Et al.
    J Cell Sci  2012;125:2436
  67. Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts.
    Authors: Kumar Et al.
    Cell Cycle  2012;11:1183
  68. Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.
    Authors: Kanai Et al.
    J Natl Cancer Inst  2012;104:42
  69. Parvovirus B19 infection of human primary erythroid progenitor cells triggers ATR-Chk1 signaling, which promotes B19 virus replication.
    Authors: Luo Et al.
    J Virol  2011;85:8046
  70. γ-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo.
    Authors: Sharma Et al.
    Gene Ther  2011;6:e28217
  71. The phenotypic radiation resistance of CD44+/CD24(-or low) breast cancer cells is mediated through the enhanced activation of ATM signaling.
    Authors: Yin and Glass
    PLoS One  2011;6:e24080
  72. Differential inhibitor sensitivity between human kinases VRK1 and VRK2.
    Authors: Vázquez-Cedeira Et al.
    PLoS One  2011;6:e23235
  73. H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.
    Authors: Helmink Et al.
    Nature  2011;469:245
  74. Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy.
    Authors: Farkas Et al.
    J Biol Chem  2011;286:38904
  75. Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death.
    Authors: Peidis Et al.
    Cell Death Differ  2011;18:145
  76. Differential effects of DNA double-strand break repair pathways on single-strand and self-complementary adeno-associated virus vector genomes.
    Authors: Cataldi and McCarty
    J Exp Med  2010;84:8673
  77. Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells.
    Authors: Qi Et al.
    Am J Physiol Cell Physiol  2010;285:33010

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