KU 55933

  ( 58 citations )    
Product Datasheet
Catalog Number:3544
Chemical Name:2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one
Product Details
Citations (58)
Reviews
Biological Activity
Potent, selective and competitive ATM kinase inhibitor (Ki = 2.2 nM, IC50 values are 13, 2500, 9300, 16600, > 100000 and > 100000 nM at ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively). Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1 levels in vitro. Acts as a radio- and chemosensitizer for the treatment of cancer.
Technical Data
  • M.Wt:
    395.49
  • Formula:
    C21H17NO3S2
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    587871-26-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for KU 55933 include:

58 Citations: Showing 1 - 10
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  1. Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy.
    Authors: Benkafadar Et al.
    EMBO Mol Med  2017;9:7
  2. Drug-induced hyperploidy stimulates an antitumor NK cell response mediated by NKG2D and DNAM-1 receptors.
    Authors: Acebes-Huerta Et al.
    Oncoimmunology  2016;5:e1074378
  3. Fe65 Is Phosphorylated on Ser289 after UV-Induced DNA Damage.
    Authors: Langlands Et al.
    PLoS One  2016;11:e0155056
  4. Activation of DNA Damage Response Pathways during Lytic Replication of KSHV.
    Authors: Hollingworth Et al.
    Mol Cell Biol  2015;7:2908
  5. Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells.
    Authors: Ahmed Et al.
    Cancer Res  2015;75:4416
  6. A radiosensitivity MiRNA signature validated by the TCGA database for head and neck squamous cell carcinomas.
    Authors: Liu Et al.
    Aging Cell  2015;6:34649
  7. DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation.
    Authors: Allen Et al.
    Front Oncol  2015;5:260
  8. Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins.
    Authors: Colin Et al.
    Viruses  2015;5:140156
  9. The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.
    Authors: Stechow Et al.
    Proc Natl Acad Sci U S A  2015;35:1254
  10. Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related.
    Authors: Beggs Et al.
    Toxicology  2015;331:35
  11. Spatio-temporal regulation of RAG2 following genotoxic stress.
    Authors: Rodgers Et al.
    DNA Repair (Amst)  2015;27:19
  12. Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage.
    Authors: Gibbs-Seymour Et al.
    Open Biol  2015;14:162
  13. Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells.
    Authors: Teng Et al.
    Gynecol Oncol  2015;136:554
  14. F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress.
    Authors: Malonia Et al.
    J Cell Biol  2015;112:8632
  15. Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells.
    Authors: Okita Et al.
    PLoS One  2015;10:e0139809
  16. TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence.
    Authors: Ye Et al.
    EMBO Mol Med  2014;6:1294
  17. SMAR1 coordinates HDAC6-induced deacetylation of Ku70 and dictates cell fate upon irradiation.
    Authors: Chaudhary Et al.
    Cell Death Dis  2014;5:e1447
  18. ATM specifically mediates repair of double-strand breaks with blocked DNA ends.
    Authors: Alvarez-Quilón Et al.
    Nat Commun  2014;5:3347
  19. Inhibition of ataxia telangiectasia mutated (ATM) kinase suppresses herpes simplex virus type 1 (HSV-1) keratitis.
    Authors: Alekseev Et al.
    Invest Ophthalmol Vis Sci  2014;55:706
  20. Defying DNA double-strand break-induced death during prophase I meiosis by temporal TAp63α phosphorylation regulation in developing mouse oocytes.
    Authors: Kim and Suh
    Mol Cell Biol  2014;34:1460
  21. The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair.
    Authors: Henriksson Et al.
    Genes Dev  2014;28:2726
  22. Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation.
    Authors: Wu Et al.
    J Biol Chem  2014;289:34378
  23. Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons.
    Authors: Sheng Et al.
    Oncotarget  2014;289:20845
  24. Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication.
    Authors: Sakai Et al.
    Cell Cycle  2014;13:1015
  25. SMC1-mediated intra-S-phase arrest facilitates bocavirus DNA replication.
    Authors: Luo Et al.
    J Virol  2013;87:4017
  26. Human papillomavirus episome stability is reduced by aphidicolin and controlled by DNA damage response pathways.
    Authors: Edwards Et al.
    J Virol  2013;87:3979
  27. Targeting XRCC1 deficiency in breast cancer for personalized therapy.
    Authors: Sultana Et al.
    Cancer Res  2013;73:1621
  28. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
    Authors: Montané and Menand
    Nat Chem Biol  2013;64:4361
  29. Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.
    Authors: Yüce and West
    Mol Cell Biol  2013;33:406
  30. Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination.
    Authors: Lee Et al.
    PLoS One  2013;33:3568
  31. Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.
    Authors: Bothmer Et al.
    Chembiochem  2013;210:115
  32. Hairpin-end conformation of adeno-associated virus genome determines interactions with DNA-repair pathways.
    Authors: Cataldi and McCarty
    J Biol Chem  2013;20:686
  33. Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells.
    Authors: Passaro Et al.
    Endocr Relat Cancer  2013;20:633
  34. A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair.
    Authors: Britton Et al.
    J Cell Biol  2013;202:579
  35. E1a promotes c-Myc-dependent replicative stress: implications in glioblastoma radiosensitization.
    Authors: Valero Et al.
    Cell Cycle  2013;13:52
  36. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway.
    Authors: Fard Et al.
    Cell Cycle  2013;13:408
  37. Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining.
    Authors: Oksenych Et al.
    J Biol Chem  2013;110:2234
  38. Role of 53BP1 oligomerization in regulating double-strand break repair.
    Authors: Lottersberger Et al.
    Proc Natl Acad Sci U S A  2013;110:2146
  39. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.
    Authors: Sullivan Et al.
    Proc Natl Acad Sci U S A  2012;8:646
  40. Mechanism-based screen establishes signalling framework for DNA damage-associated G1 checkpoint response.
    Authors: Richardson Et al.
    PLoS One  2012;7:e31627
  41. PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling.
    Authors: Ando Et al.
    Mol Cell  2012;47:681
  42. SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response.
    Authors: Mund Et al.
    Nucleic Acids Res  2012;40:11363
  43. Regulation of SIRT1 activity by genotoxic stress.
    Authors: Yuan Et al.
    Genes Dev  2012;26:791
  44. Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice.
    Authors: Yamamoto Et al.
    J Virol  2012;198:305
  45. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation.
    Authors: Fumagalli Et al.
    Nat Cell Biol  2012;14:355
  46. Detection of early Abl kinase activation after ionizing radiation by using a peptide biosensor.
    Authors: Tang Et al.
    Mol Cell Biol  2012;13:665
  47. Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors.
    Authors: Sultana Et al.
    Int J Cancer  2012;131:2433
  48. Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation.
    Authors: Klotz-Noack Et al.
    J Cell Sci  2012;125:2436
  49. Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts.
    Authors: Kumar Et al.
    Cell Cycle  2012;11:1183
  50. Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.
    Authors: Kanai Et al.
    J Natl Cancer Inst  2012;104:42
  51. γ-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo.
    Authors: Sharma Et al.
    Gene Ther  2011;6:e28217
  52. The phenotypic radiation resistance of CD44+/CD24(-or low) breast cancer cells is mediated through the enhanced activation of ATM signaling.
    Authors: Yin and Glass
    PLoS One  2011;6:e24080
  53. Differential inhibitor sensitivity between human kinases VRK1 and VRK2.
    Authors: Vázquez-Cedeira Et al.
    PLoS One  2011;6:e23235
  54. H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.
    Authors: Helmink Et al.
    Nature  2011;469:245
  55. Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy.
    Authors: Farkas Et al.
    J Biol Chem  2011;286:38904
  56. Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death.
    Authors: Peidis Et al.
    Cell Death Differ  2011;18:145
  57. Differential effects of DNA double-strand break repair pathways on single-strand and self-complementary adeno-associated virus vector genomes.
    Authors: Cataldi and McCarty
    J Exp Med  2010;84:8673
  58. Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells.
    Authors: Qi Et al.
    Am J Physiol Cell Physiol  2010;285:33010
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