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1 result for "Beta-Catenin Antagonists Small Molecules and Peptides" in Products
Beta-Catenin Antagonists Small Molecules and Peptides
β-catenin protein is an integral part of the canonical Wnt signaling pathway. Wnt binding to Frizzled (Fz) receptors and LRP co-receptors activates Dishevelled (Dsh) proteins; these in turn inhibit the destruction complex responsible for degrading β-catenin, which includes GSK-3, adenomatous polyposis coli (APC) and axin. Accumulation of β-catenin in the cell cytoplasm prompts its translocation to the nucleus, where it interacts with members of the TCF/LEF family of ...
| Alternate Names: | UCN 1028C,PKF 115584 |
| Chemical Name: | (1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonic acid 4-hydroxyphenyl ester |
| Purity: | ≥95% |
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