BLIMP1/PRDM1 Proteins and Enzymes

BLIMP1 (also known as PRDM1) is a zinc-finger transcriptional repressor that promotes B cell maturation into plasma cells. It contains an N-terminal SET domain and four C-terminal C2H2-type zinc-finger motifs. The SET domain interacts with chromatin modifiers, while the zinc fingers bind to DNA. In addition to its role in the immune system, murine BLIMP1 is also required for formation of primordial germ cells.