Bromodomain Compounds Fluorescent Probes and Dyes

Bromodomain Structure and Function

There are approximately 61 unique human Bromodomains. These protein modules have been identified in 42 proteins with diverse functions from the histone acetyltransferase (HAT) PCAF, which adds acetyl groups to lysine residues on histone tails, to the ATP-dependent helicase SNF2L2. This diversity has made it difficult to characterize the function of a given BRD-containing protein, particularly as some proteins may contain one or more additional epigenetic ...