Cav1.x Channel Blockers

Ca_V1.x channels (L-type) are high-voltage activated Ca²⁺ channels that are sensitive to blockade by dihydropyridines. This family has four members, each composed of an α₁, α₂/δ, β and γ subunit.

Ca_V1.1 channels are specific to skeletal muscle where they interact with ryanodine receptors on the sarcoplasmic reticulum and trigger Ca²⁺ influx, Ca²⁺-activated Ca²⁺ release and muscle contraction. Mutations in Ca_V1.1 α₁-subunit have been linked to hypokalemic periodic ...