3 results for "Constitutive Androstane Receptor Inverse Agonists" in Products

Constitutive Androstane Receptor Inverse Agonists

The constitutive androstane receptor (CAR) is a member of the NR1I family of nuclear receptors, along with the pregnane X receptor and vitamin D receptor. CAR is involved in the sensing and clearance of foreign toxins through the upregulation of genes involved in xenobiotic clearance, including cytochrome P450, bilirubin, and multidrug transporters.

The name 'constitutive androstane receptor' refers to the unusual, constitutively active status of this receptor when not occupied by a ...

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Potent liver X receptor (LXR) agonist; also CAR inverse agonist

Chemical Name: N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide
Purity: ≥98%
Potent liver X receptor (LXR) agonist; also CAR inverse agonist
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Selective CAR agonist

Chemical Name: 6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime
Purity: ≥98%
Selective CAR agonist
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Cytochrome P450 inhibitor; antifungal

Alternate Names: CLT
Chemical Name: 1-(2-Chloro-α,α-diphenylbenzyl)imidazole
Purity: ≥98%
Cytochrome P450 inhibitor; antifungal
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