Death-associated Protein Kinase (DAPK) Inhibitors

The death-associated protein kinase (DAPK) family contains three closely-related members: DAPK (also known as DAPK1), DAPK-related protein 1 (DRP-1) and ZIP kinase (ZIPK), all of which are serine/threonine kinases involved in apoptotic and autophagic cell death. Recent research has suggested that these three kinases interact to form complexes which transmit cell death signals in response to stresses such as detachment from the extracellular membrane, and stimuli including TNF-α, IFN-γ ...