Kinases

Kinases (also known as phosphotransferases) catalyze phosphorylation. They enable the transfer of the chemically labile γ phosphoryl group from ATP or other nucleoside triphosphates to alcohol or amino group acceptors. Acceptors may be small organic molecules (e.g. glucose) or macromolecules (e.g. proteins) and the phosphorylated form of the acceptor may be more or less active than the non-phosphorylated form. Kinases are widely involved in signal transduction pathways and control complex cellular functions.

Kinase Targets

Abl Kinase (Abl Kinase)

Cyclin-Dependent Kinases (CDKs)

MAPK Family (MAPK)

Pim Kinase (Pim Kinase)

Ack1 (Ack1)

Death-Associated Protein Kinase (DAPK)

MEK Family (MEK1, MEK2, MEK5)

Polo-like Kinase Family (PLK1, PLK2, PLK3, PLK4, PLK5)

Adenosine Kinase (ADK)

DNA-Dependent Protein Kinase (DNA-PK)

MK2 (MAPKAPK2)

Protein Kinase A (PKA)

Akt (Protein Kinase B) (Akt)

DYRK (DYRK)

Mnk

Protein Kinase C (PKC)

AMPK (AMPK)

Focal Adhesion Kinase (FAK)

Monopolar Spindle 1 Kinase (TTK Protein Kinase)

Protein Kinase D (PKD)

ASK1 (ASK1)

Glycogen Synthase Kinase 3 (GSK-3)

mTOR (mTOR)

Protein Kinase G

ATM and ATR Kinases

Haspin (GSG2)

Myosin Light Chain Kinase (MLCK)

Raf Kinases (Raf Kinases)

Aurora Kinases (Aurora Kinases)

Hexokinases (Hexokinases)

Nek2 Kinase (Nek2)

Receptor Interacting Protein Kinase Family (RIP1, RIP2, RIP3, RIP4)

Bruton's Tyrosine Kinase (BTK)

IκB Kinase (IKK)

NUAK Family (NUAK1, NUAK2)

Rho-Kinases

CaM Kinase (CaMK)

IRAK Family (IRAK1, IRAK2, IRAK3, IRAK4)

P21-activated Kinases (PAK)

RSK (RSK)

Casein Kinase 1 (CK1)

ITK (ITK)

PERK (PERK)

Sphingosine Kinase Family (SphK1, SphK2)

Casein Kinase 2 (CK2)

JAK Family (Jak1, Jak2, Jak3)

PFKFB3 (PFKFB3)

Src Kinases (Src Kinases)

Checkpoint Kinases (Chk)

LIMK Family (LIMK1, LIMK2)

Phosphoinositide-dependent Kinase 1 (PDK-1)

Syk Kinase (Syk)

CLK (Cdc2-like Kinases)

LRRK2 (LRRK2)

PI 3-kinase (PI 3-K)

TANK Binding Kinase (TBK)

Related Targets

Broad Spectrum Protein Kinase Inhibitors

PI 3-Kinase/Akt Signaling

MAPK Signaling

Receptor Serine/Threonine Kinases (RSTKs)

Other Kinase Targets

Receptor Tyrosine Kinases (RTKs)

Literature

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

  • Glycolysis
  • Tricarboxylic Acid Cycle
  • Lipidogenesis
  • 1C Metabolism and Nucleic Acid Synthesis
  • Drivers of Metabolic Reprogramming
  • pH and Redox Balance