3 results for "Degrader Building Blocks Small Molecules and Peptides" in Products

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Degrader Building Blocks Small Molecules and Peptides

Tocris provides Building Blocks to support Degrader research and development. Degraders (e.g. PROTAC® molecules, SNIPERs etc) are heterobifunctional small molecules that are modular in design, comprising binding moieties for an E3 ubiquitin ligase and a target protein joined by a linker. Our Degrader components have functional handles for easy conjugation to ligands/linkers of interest. The range includes the most effective and commonly used E3 ubiquitin ligase ligands, functionalized at ...

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cis VH 032, amine dihydrochloride

Catalog #: 6969
Product Documents

Negative control for VH 032, amine (Cat. No. 6462)

Alternate Names: (S,S,S)-AHPC
Chemical Name: (2S,4S)-1-[(2S)-2-Amino-3,3-dimethyl-butanoyl]-4-hydroxy-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥98%
Negative control for VH 032, amine (Cat. No. 6462)

N-methylated pomalidomide

Catalog #: 7716
Product Documents

Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control

Chemical Name: 4-Amino-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95%
Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control

(+)-JQ1 bump-N, acid functionalized

Catalog #: 8827
Product Documents

Negative control for (+)-JQ1 bump, acid functionalized (Cat. No. 7689)

Chemical Name: (S)-2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)butanoic acid
Purity: ≥98%
Negative control for (+)-JQ1 bump, acid functionalized (Cat. No. 7689)
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