3 results for "Glucagon-Like Peptide 1 Receptor Antagonists" in Products
Glucagon-Like Peptide 1 Receptor Antagonists
Glucagon-like peptide 1 (GLP-1) receptors are members of the glucagon receptor family that also includes glucagon, GLP-2, secretin, GHRH and GIP receptors. GLP-1 receptors are found both centrally (hypothalamus and brainstem) and peripherally (pancreatic islet cells, stomach and heart).
GLP-1 receptors mediate the effects of the incretin axis; the functional connection between the intestine and the islets of Langerhans in the pancreas. Activation stimulates insulin release from the islet β-cells in a glucose-dependent manner and suppresses glucagon secretion from islet α-cells. In addition, GLP-1 receptors delay gastric emptying and regulate appetite. The human GLP-1 receptor gene is localized on chromosome 6p21.
Potent GLP-1 receptor antagonist
| Purity: | ≥95% |
Metabolite of GLP-1-(7-36) (Cat. No. 2082)
| Alternate Names: | Glucagon-like peptide 1 (9-36) amide |
| Purity: | ≥95% |
Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant
| Chemical Name: | 7-(4-Chlorophenyl)-5,8-dihydro-1,3-dimethyl-5,5-bis(trifluoromethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione |
| Purity: | ≥98% |
