Potent and selective GLP-1 receptor antagonist (Kd
= 1.7 nM at cloned human GLP-1 receptors). Inhibits cAMP production and insulin release induced by GLP-1 (7-36), exendin-3 (IC50
= 20 nM) and exendin-4. Blocks the inhibitory effect of GLP-1 on food intake in rats.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting β-cells.
Goke et al.
Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor.
Thorens et al.
A role for glucagon-like peptide-1 in the central regulation of feeding.
Turton et al.
Exendin-3, a novel peptide from the Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas.
Raufman et al.
The citations listed below are publications that use Tocris products. Selected citations for Exendin-3 (9-39) amide include:
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