Biological ActivityPotent and selective GLP-1 receptor antagonist (Kd = 1.7 nM at cloned human GLP-1 receptors). Inhibits cAMP production and insulin release induced by GLP-1 (7-36), exendin-3 (IC50 = 20 nM) and exendin-4. Blocks the inhibitory effect of GLP-1 on food intake in rats.
(Modifications: Ser-31 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A role for glucagon-like peptide-1 in the central regulation of feeding.
Turton et al.
Exendin-3, a novel peptide from the Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas.
Raufman et al.
Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of Ins-Secr.g β-cells.
Goke et al.
Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor.
Thorens et al.
Citations for Exendin-3 (9-39) amide
The citations listed below are publications that use Tocris products. Selected citations for Exendin-3 (9-39) amide include:
5 Citations: Showing 1 - 5
Glucagon-like peptide-1 receptors within the nucleus of the solitary tract regulate alcohol-mediated behaviors in rodents.
Authors: Vallof Et al.
Lactobacillus gasseri in the Upper Small Intestine Impacts an ACSL3-Dependent Fatty Acid-Sensing Pathway Regulating Whole-Body Glucose Homeostasis.
Authors: Bauer Et al.
Cell Metab 2018;27:572
GLP-1 acts on habenular avoidance circuits to control nicotine intake.
Nat Neurosci 2017;20(5):708
Negative Energy Balance Blocks Neural and Behavioral Responses to Acute Stress by " Silencing" Central Glucagon-Like Peptide 1 Signaling in Rats.
Authors: Maniscalco Et al.
Emerg Microbes Infect 2015;35:10701
The role of the gut hormone GLP-1 in the metabolic improvements caused by ileal transposition.
Authors: Gaitonde Et al.
J Surg Res 2012;178:33
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