Exendin-3 (9-39) amide

  ( 3 citations )    
Product Datasheet
Catalog Number:2081
Chemical Name:
Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity
Potent and selective GLP-1 receptor antagonist (Kd = 1.7 nM at cloned human GLP-1 receptors). Inhibits cAMP production and insulin release induced by GLP-1 (7-36), exendin-3 (IC50 = 20 nM) and exendin-4. Blocks the inhibitory effect of GLP-1 on food intake in rats.
Technical Data
  • M.Wt:
    3369.79
  • Formula:
    C149H234N40O47S
  • Sequence:
    DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

    (Modifications: Ser-31 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    133514-43-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Exendin-3 (9-39) amide include:

3 Citations: Showing 1 - 3
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  1. GLP-1 acts on habenular avoidance circuits to control nicotine intake.
    Authors: Tuesta
    Nat Neurosci  2017;20(5):708
  2. Negative Energy Balance Blocks Neural and Behavioral Responses to Acute Stress by " Silencing" Central Glucagon-Like Peptide 1 Signaling in Rats.
    Authors: Maniscalco Et al.
    Emerg Microbes Infect  2015;35:10701
  3. The role of the gut hormone GLP-1 in the metabolic improvements caused by ileal transposition.
    Authors: Gaitonde Et al.
    J Surg Res  2012;178:33

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