Group I mGluR Antagonists Small Molecules and Peptides

Metabotropic glutamate (mGlu) group I receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group II and mGlu group III receptors. mGlu group I receptors are divided into two subtypes, mGlu₁ and mGlu₅. Group I mGluRs are coupled to G_q/11, which activates phospholipase C. They are also associated with Na⁺ and K⁺ channels. Their action is generally excitatory, increasing conductance, causing more glutamate to be released from the presynaptic cell. They ...