receptor non-competitive antagonist (IC50
= 0.16 μ
M) with inverse agonist activity. Impairs classical conditioning and associated synaptic plasticity in hippocampal neurons. Exhibits neuroprotective and anticonvulsive effects in vivo
following systemic administration.
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BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity.
Carroll et al.
Neuroprotective and behavioural effects of the selective metabotropic glutamate mGlu1 receptor antagonist BAY 36-7620.
De Vry et al.
Involvement of the mGluR1 receptor in hippocampal synaptic plasticity and associative learning in behaving mice.
Gil-Sanz et al.
The citations listed below are publications that use Tocris products. Selected citations for Bay 36-7620 include:
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