Chemical Name: (3aS,6aS)-Hexahydro-5-methylene-6a-(2-naphthalenylmethyl)-1H-cyclopenta[c]furan-1-one
Biological ActivitySelective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity. Impairs classical conditioning and associated synaptic plasticity in hippocampal neurons. Exhibits neuroprotective and anticonvulsive effects in vivo following systemic administration.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity.
Carroll et al.
Neuroprotective and behavioural effects of the selective metabotropic glutamate mGlu1 receptor antagonist BAY 36-7620.
De Vry et al.
Involvement of the mGluR1 receptor in hippocampal synaptic plasticity and associative learning in behaving mice.
Gil-Sanz et al.
Citations for Bay 36-7620
The citations listed below are publications that use Tocris products. Selected citations for Bay 36-7620 include:
9 Citations: Showing 1 - 9
Metabotropic glutamate receptor-1 regulates inflammation in triple negative breast cancer.
Authors: Sexton Et al.
Sci Rep 2018;8:16008
R.zole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells.
Authors: Dolfi Et al.
Mechanisms of tau and Aβ-induced excitotoxicity.
Authors: Pallo Et al.
Brain Res 2016;1634:119
Disruption of GRM1-mediated signalling using R.zole results in DNA damage in melanoma cells.
Authors: Wall Et al.
Pigment Cell Melanoma Res 2014;27:263
Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation.
Authors: Veettil Et al.
PLoS Pathog 2014;10:e1004389
Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer.
Authors: Speyer Et al.
Breast Cancer Res Treat 2012;132:565
Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear.
Authors: Tronson Et al.
The glutamate release inhibitor R.zole decreases migration, invasion, and proliferation of melanoma cells.
Authors: Le Et al.
J Invest Dermatol 2010;130:2240
mGluR(1) Receptors Contribute to Non-Purinergic Slow Excitatory Transmission to Submucosal VIP Neurons of Guinea-Pig Ileum.
Front Neurosci 2009;3:46
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