Catalog Number: 2501
Chemical Name: (3aS,6aS)-Hexahydro-5-methylene-6a-(2-naphthalenylmethyl)-1H-cyclopenta[c]furan-1-one
Biological Activity
Selective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity. Impairs classical conditioning and associated synaptic plasticity in hippocampal neurons. Exhibits neuroprotective and anticonvulsive effects in vivo following systemic administration.
Technical Data
  • M.Wt:
    278.35
  • Formula:
    C19H18O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    232605-26-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Bayer
Background References
  1. BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity.
    Carroll et al.
    Mol.Pharmacol., 2001;59:965
  2. Neuroprotective and behavioural effects of the selective metabotropic glutamate mGlu1 receptor antagonist BAY 36-7620.
    De Vry et al.
    Eur.J.Pharmacol., 2001;428:203
  3. Involvement of the mGluR1 receptor in hippocampal synaptic plasticity and associative learning in behaving mice.
    Gil-Sanz et al.
    Cereb.Cortex, 2007;18:1653
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Bay 36-7620 include:

4 Citations: Showing 1 - 4
Filter your results:

  1. Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cells.
    Authors: Wall Et al.
    Pigment Cell Melanoma Res 2014;27:263
  2. Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation.
    Authors: Veettil Et al.
    PLoS Pathog 2014;10:e1004389
  3. Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear.
    Authors: Tronson Et al.
    Autophagy 2010;68:1007
  4. The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells.
    Authors: Le Et al.
    J Invest Dermatol 2010;130:2240

Have you used Bay 36-7620?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information