Catalog Number: 2501
Chemical Name: (3aS,6aS)-Hexahydro-5-methylene-6a-(2-naphthalenylmethyl)-1H-cyclopenta[c]furan-1-one
Biological Activity
Selective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity. Impairs classical conditioning and associated synaptic plasticity in hippocampal neurons. Exhibits neuroprotective and anticonvulsive effects in vivo following systemic administration.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Bayer
Background References
  1. BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity.
    Carroll et al.
    Mol.Pharmacol., 2001;59:965
  2. Neuroprotective and behavioural effects of the selective metabotropic glutamate mGlu1 receptor antagonist BAY 36-7620.
    De Vry et al.
    Eur.J.Pharmacol., 2001;428:203
  3. Involvement of the mGluR1 receptor in hippocampal synaptic plasticity and associative learning in behaving mice.
    Gil-Sanz et al.
    Cereb.Cortex, 2007;18:1653
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