Group II mGluR Agonists

Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided into two subtypes, mGlu₂ and mGlu₃. mGlu group II receptors are coupled to G_i/o, which inhibits adenylyl cyclase, decreasing the formation of cAMP. These receptors are involved in presynaptic inhibition and do not appear to affect postsynaptic membrane potential by themselves. The human genes for mGlu₂ and mGlu₃ receptors have been localized to chromosomes 3 (p21.1) and 7 (7q21.1-q21.2) respectively.