Biological Activity(S)-4-Carboxyphenylglycine is a competitive group I metabotropic glutamate receptor antagonist, with selectivity for mGlu1a/1a over mGlu5a/5b.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Phenylglycine derivatives discriminate between mGluR1-and mGluR5-mediated responses.
Brabet et al.
Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system.
Birse et al.
Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG).
Eaton et al.
Antagonist activity of α-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells.
Doherty et al.
Citations for (S)-4-Carboxyphenylglycine
The citations listed below are publications that use Tocris products. Selected citations for (S)-4-Carboxyphenylglycine include:
7 Citations: Showing 1 - 7
Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming.
Authors: Riz Et al.
Repeated cycles of chronic intermittent ethanol exposure increases basal glutamate in the nucleus accumbens of mice without affecting glutamate transport.
Authors: Griffin Et al.
Front Pharmacol 2015;6:27
Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors.
Authors: Mahler Et al.
J Young Investig 2014;19:49
Augmented cystine-glutamate exchange by pituitary adenylate cyclase-activating polypeptide signaling via the VPAC1 receptor.
Authors: Resch Et al.
Cytokine Production Modified by System X(c)- After PM10 and Asbestos Exposure.
Authors: Overocker and Pfau
Proc Natl Acad Sci U S A 2012;23:34
Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin.
Authors: Liu Et al.
Mol Pharmacol 2007;72:1637
Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity.
Authors: Porter Et al.
J Pharmacol Exp Ther 2005;315:711
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Treatment with (S)-4-carboxyphenylglycine (CPG) ensitizes LP-1/Cfz cells. Cellswere treated with the indicated concentrations of carfilzomib for 72 hours in the absence or presence of CPG (0.2 uM)