Catalog Number: 0323
Alternate Names: (S)-4CPG
Biological Activity
Competitive group I metabotropic glutamate receptor antagonist, with selectivity for mGlu1a/1a over mGlu5a/5b. (RS)-4-Carboxyphenylglycine (Cat. No. 0321) and (R)-4-Carboxyphenylglycine (Cat. No. 0322) also available.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH with gentle warming
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Phenylglycine derivatives discriminate between mGluR1-and mGluR5-mediated responses.
    Brabet et al.
    Neuropharmacology, 1995;34:895
  2. Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system.
    Birse et al.
    Neuroscience, 1993;52:481
  3. Antagonist activity of α-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells.
    Doherty et al.
    Br.J.Pharmacol., 1999;126:205
  4. Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG).
    Eaton et al.
    Eur.J.Pharmacol., 1993;244:195
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