JAK Degraders Small Molecules and Peptides

Janus kinases (or JAKs) are a family of nonreceptor tyrosine kinases that function downstream of cytokine receptors. Following activation of a cytokine receptor JAKs phosphorylate the transcription factors known as STATs and initiate the JAK-STAT signaling pathway. Four JAK family members have been identified (JAK1, JAK2, JAK3 and Tyk2), which share a similar protein domain structure: a kinase domain (JH1), a 'pseudo'-kinase domain that regulates the kinase activity of JH1, a SH2 domain ...