SJ 1008030

Tocris Bioscience | Catalog # 7675

Selective JAK2 Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Selective JAK2 Degrader (PROTAC®)
View all Active Degraders »

Product Description

SJ 1008030 is a potent and selective JAK2 Degrader (PROTAC®). This compound shows potent antileukemic efficacy in CRLF2r ALL (Acute Lymphoblastic Leukemia) cell lines (EC50 = 5.4 nM). SJ 1008030 induces dose-dependent JAK2 degradation (IC50 = 32 nM) in xenograft models of kinase-driven ALL, with no effect on GSPT1 levels.

JAK2 antibodies validated for Western Blot also available: Catalog # NBP2-59451 and AF2988.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from St. Jude Children's Research Hospital

Product Specifications for SJ 1008030

Molecular Weight

987.97

Formula

C42H43N13O7S.CF3CO2H

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethyl)benzamide trifluoroacetate

CAS Number

2863634-97-1

InChI Key

RRJQTSMHAOAMTD-UHFFFAOYSA-N

SMILES

CCS(=O)(N1CC(C1)(N2C=C(C3=C4C=CNC4=NC(NC5=CC=C(C(NCCN6CCN(C7=CC=C8C(N(C(C8=C7)=O)C9CCC(NC9=O)=O)=O)CC6)=O)C=C5)=N3)C=N2)CC#N)=O.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.4 50

Preparing Stock Solutions for SJ 1008030

The following data is based on the product molecular weight 987.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.02 mL 10.12 mL 20.24 mL
2.5 mM 0.40 mL 2.02 mL 4.05 mL
5 mM 0.20 mL 1.01 mL 2.02 mL
25 mM 0.04 mL 0.20 mL 0.40 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SJ 1008030

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SJ 1008030

For research use only

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