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4 results for "Molecular Glues" in Products
Molecular Glues
What are Molecular Glues?
Molecular Glues are small molecules that achieve targeted protein degradation by bringing about dimerization of target proteins with ubiquitin E3 ligases. This "degradation-by-dimerization" effect may occur either by direct binding interactions between an E3 ligase and the protein of interest, with the small molecule at the protein-protein interface. Alternatively binding of the molecular glue leads to allosteric modification of the E3 ligase protein ...
Cdk inhibitor; potently inhibits cdk1 and cdk2; also inhibits CK1; acts as molecular glue
| Chemical Name: | (2R)-2-[[9-(Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-1-butanol trihydrochloride |
| Purity: | ≥98% |
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α2 integrin inhibitor; anti-angiogenic
| Chemical Name: | 3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide |
| Purity: | ≥98% |
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Covalent allosteric NRF2 inhibitor
| Chemical Name: | 1-[(3R)-3-[3-(4-Amino-1,3,5-triazin-2-yl)-5-chlorophenyl]-4-morpholinyl]-2-propen-1-one |
| Purity: | ≥98% |
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CBL-B intramolecular glue inhibitor
| Chemical Name: | 2,3-Dihydro-2-[3-[cis-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-6-[[(3S)-3-methyl-1-piperidinyl]methyl]-4-(trifluoromethyl)-1H-isoindol-1-one |
| Purity: | ≥98% |
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