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3 results for "Nicotinic (a4b2) Receptor Modulators" in Products
Nicotinic (a4b2) Receptor Modulators
Nicotinic α4β2 receptors have high affinity for nicotine and account for >90% of [3H]-nicotine binding to brain tissues. A stoichiometry of (α4)2(β2)3 has been proposed, generating two agonist binding sites consistent with the model of the muscle nAChR.
Manipulation of the stoichiometry of α4β2 nAChRs expressed in Xenopus oocytes indicates that (α4)3(β2)2 nAChRs are also viable, displaying lower affinity for ACh and higher Ca2+ permeability; whether ...
Positive allosteric modulator of α4β2 nAChRs; also muscle-type nAChR inhibitor
| Chemical Name: | 6-Bromo-2-(1,1-dimethyl-2-propenyl)-N-1H-indole-3-ethanamine hydrochloride |
| Purity: | ≥98% |
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Allosteric potentiator of α7, α4β2 and α4β4 nAChRs
| Chemical Name: | [2-[(4-Fluorophenyl)amino]-4-methyl-5-thiazolyl]-3-thienylmethanone |
| Purity: | ≥98% |
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Positive allosteric modulator of α4β2 nAChRs
| Chemical Name: | 3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile |
| Purity: | ≥98% |
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