Chemical Name: [2-[(4-Fluorophenyl)amino]-4-methyl-5-thiazolyl]-3-thienylmethanone
Biological ActivityLY 2087101 is an allosteric potentiator of α7, α4β2 and α4β4 nAChRs; displays selectivity against α3β4 nAChRs. Thought to potentiate agonist-evoked α7 responses by binding within the nAChR transmembrane region.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators.
Broad et al.
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VersaClone cDNA Plasmids
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