Allosteric potentiator of α
2 and α
4 nAChRs; displays selectivity against α
4 nAChRs. Thought to potentiate agonist-evoked α
7 responses by binding within the nAChR transmembrane region.
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Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators.
Broad et al.
Potentiation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site.
Young et al.