Chemical Name: [2-[(4-Fluorophenyl)amino]-4-methyl-5-thiazolyl]-3-thienylmethanone
Biological ActivityAllosteric potentiator of α7, α4β2 and α4β4 nAChRs; displays selectivity against α3β4 nAChRs. Thought to potentiate agonist-evoked α7 responses by binding within the nAChR transmembrane region.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators.
Broad et al.
Potentiation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site.
Young et al.
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VersaClone cDNA Plasmids
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