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3 results for "Nrf2" in Products
Nrf2 Products
NF-E2 related factor 2 (Nrf2) is a member of the cap 'n collar family of basic leucine zipper transcription factors. By binding antioxidant response elements (AREs), Nrf2 activates the transcription of genes encoding antioxidant and phase II drug-metabolizing enzymes needed to protect cells against oxidative damage. Transcriptional targets regulated by Nrf2 include genes encoding glutathione S-transferases, superoxide dismutase-1, and heme oxygenase-1.
Nrf2 inhibitor; phenotypically lethal
| Chemical Name: | N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide |
| Purity: | ≥98% |
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PGK1 inhibitor; activates Nrf2
| Chemical Name: | (3R,4S)-rel-4-[(4-Chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-3-thiophenamine-1,1-dioxide |
| Purity: | ≥98% |
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Covalent allosteric NRF2 inhibitor
| Chemical Name: | 1-[(3R)-3-[3-(4-Amino-1,3,5-triazin-2-yl)-5-chlorophenyl]-4-morpholinyl]-2-propen-1-one |
| Purity: | ≥98% |
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