ML 385

Tocris Bioscience | Catalog # 6243

Nrf2 inhibitor; phenotypically lethal
Tocris Bioscience

Key Product Details

Description

Nrf2 inhibitor; phenotypically lethal
View all Nrf2 Inhibitors »

Product Description

ML 385 is an Nrf2 inhibitor. Blocks Nrf2 downstream target gene expression. Enhances cytotoxic effects of doxorubicin (Cat. No. 2252) or Taxol (Cat. No. 1097) in non-small cell lung cancer (NSCLC). Demonstrates selectivity for NSCLC cells with KEAP1 mutations.

Product Specifications for ML 385

Molecular Weight

511.59

Formula

C29H25N3O4S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide

CAS Number

846557-71-9

PubChem ID

1383822

InChI Key

LINHYWKZVCNAMQ-UHFFFAOYSA-N

SMILES

CC1=C(C2=CC=C3N(C(C4=C(C=CC=C4)C)=O)CCC3=C2)N=C(S1)NC(CC5=CC=C6OCOC6=C5)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.58 50

Preparing Stock Solutions for ML 385

The following data is based on the product molecular weight 511.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.91 mL 19.55 mL 39.09 mL
2.5 mM 0.78 mL 3.91 mL 7.82 mL
5 mM 0.39 mL 1.95 mL 3.91 mL
25 mM 0.08 mL 0.39 mL 0.78 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for ML 385

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ML 385

For research use only

Customer Reviews for ML 385 (1)

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  • Inhibition of nrf2 in mouse macrophages
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: macrophage
    Verified Customer | Posted 09/24/2019
    Used to inhibit nrf2

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