ML 385

Catalog # Availability Size / Price Qty
6243/5
6243/25
ML 385 | CAS No. 846557-71-9 | Nrf2 Inhibitors
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Description: Nrf2 inhibitor; phenotypically lethal

Chemical Name: N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide

Product Details
Reviews (1)

Biological Activity

Nrf2 inhibitor. Blocks Nrf2 downstream target gene expression. Enhances cytotoxic effects of doxorubicin (Cat. No. 2252) or Taxol (Cat. No. 1097) in non-small cell lung cancer (NSCLC). Demonstrates selectivity for NSCLC cells with KEAP1 mutations.

Technical Data

Formula:
C29H25N3O4S
Solubility:
Soluble to 50 mM in DMSO
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
846557-71-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Inhibition of nrf2 in mouse macrophages
By Anonymous on 09/24/2019
Species: Mouse

Used to inhibit nrf2


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