Nuclear Pore Complex Protein Nsp1p Products

The Nuclear pore complex (NPC) has a molecular mass of approx. 125 KDa in vertebrates and contains about 50 or more different proteins . The NPC spans the dual membrane of the the nuclear envelope (NE) and acts as a gateway for macromolecular traffic between the cytoplasm and the nucleus. The basic framework of the NPC consists of a central core with a ring-spoke structure exhibiting 8 fold radial symmetry. From this central ring 50 to 100 nm fibrils extend into the nucleoplasm and the ...