PERK Inhibitors: Products

PERK, a type 1 endoplasmic reticulum (ER) membrane kinase, mediates eIF2 alpha phosphorylation at Ser51 during the UPR (unfolded protein response). Protein synthesis is inhibited, thereby reducing the burden of protein substrate for the ER folding and degradation mechanism.

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AMG PERK 44 

Potent and selective PERK inhibitor; orally bioavailable

GSK 2606414 

Potent and selective PERK inhibitor; orally bioavailable
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