AMG PERK 44

Key Product Details

Product Description

AMG PERK 44 is a potent and selective PERK inhibitor (IC₅₀ = 6 nM). Exhibits >160-fold selectivity for PERK over B-Raf and GCN2, as well as a panel of 387 other kinases. Orally bioavailable.

Licensing Information

By permission of the authors

Product Specifications for AMG PERK 44

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AMG PERK 44

The following data is based on the product molecular weight 561.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	8.91 mL	44.56 mL	89.12 mL
1 mM	1.78 mL	8.91 mL	17.82 mL
2 mM	0.89 mL	4.46 mL	8.91 mL
10 mM	0.18 mL	0.89 mL	1.78 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 26 publications citing the usage of this product.

• Smith Discovery of 1H-pyrazol-3(2H)-ones as potent and selective inhibitors of protein kinase R-like endoplasmic reticulum kinase (PERK). J.Med.Chem. 2015 PMID: 25587754

Product Documents for AMG PERK 44