Protein Dimerizers

Protein dimerizers, also known as chemical inducers of dimerization (CIDs), are chemical compounds which bind two different proteins and bring them into close proximity solely in the presence of the dimerizer. They are commonly used to build protein complexes.

This is sometimes a natural process, as is the case with rapamycin, an antifungal compound that binds both FK506-binding protein (FKBP12) and FKBP-rapamycin binding protein (FRB). Another example of a natural dimerizer is gibberellin ...