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3 results for "RIPK3/RIP3 Small Molecules and Peptides" in Products
RIPK3/RIP3 Small Molecules and Peptides
RIPK3 (), also known as RIP3, is a 518 amino acid (aa), 60 kDa phosphoprotein that contains an N-terminal protein kinase domain and a C-terminal interaction motif with which it binds RIPK1. It converts cell response to TNF-alpha from apoptosis (RIPK1 via Fas) to programmed necrosis (RIPK1/RIPK3) by inducing reactive oxygen species production. Alternately spliced human beta (252 aa) and gamma (231 aa) isoforms diverge after aa 219 and 221, respectively, and are found to antagonize RIP3.
Potent and selective RIP3 kinase inhibitor
| Chemical Name: | N-5-Benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine |
| Purity: | ≥98% |
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Necroptosis inhibitor; also inhibits pyroptosis
| Chemical Name: | (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide |
| Purity: | ≥98% |
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Potent and selective RIPK3 inhibitor; also blocks activation of necroptosis
| Chemical Name: | 3-(3-Hydroxyphenyl)-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino]-1,6-naphthyridin-2(1H)-one dihydrochloride |
| Purity: | ≥98% |
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