Semaphorin 6A Proteins and Enzymes

Semaphorin 6A (Sema6A) is a transmembrane protein that interacts with Plexin A4 to induce growth cone collapse and regulate the axon pathfinding of sympathetic neurons, cerebellar cortex granule cells, hippocampus CA3 region mossy fibers, corticospinal tract axons, and retinal neurons. Plexin A2 can limit axon repulsion by competing with Plexin A4 for Sema6A binding. Sema6A is additionally expressed on vascular endothelial cells where it regulates VEGF R2 responsiveness during angiogenesis. It is also expressed on myelinating oligodendrocytes, Langerhans cells, and some dendritic cells.