TGF-beta Receptor Inhibitors

Transforming growth factor-β is a cytokine involved in the regulation of many cellular processes, including cell division, differentiation, motility, adhesion and death. There are three known isoforms of TGF-β in mammals, which are synthesized as inactive precursor proteins comprising an N-terminal signal peptide (pre-region), a pro-region known as latency associated peptide (LAP), and a C-terminal region that becomes the active TGF-β molecule. These inactive TGF-β ...