4 results for "TIM-3" in Products
TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
For use with catalog number DTIM30
| Reactivity: | Human |
| Applications: | Ctrl |
| Reactivity: | Human |
| Sensitivity: | 8.75 pg/mL |
| Assay Range: | 31.3-2000 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, EDTA Plasma, Heparin Plasma, Urine) |
| Applications: | ELISA |
| Reactivity: | Human |
| Assay Range: | 62.5-4000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human |
| Sensitivity: | 31.25 pg/ml (example only; lot dependent) |
| Assay Range: | 31.25-2000 pg/ml (example only; lot dependent) |
| Applications: | ELISA |
