Human TIM-3 Quantikine ELISA Kit Summary
Cell Culture Supernates, Cell Lysates, Serum, EDTA Plasma, Heparin Plasma, Urine
|Intra-Assay Precision||Inter-Assay Precision|
The recovery of human TIM-3 spiked to levels throughout the range of the assay in various matrices was evaluated
|Sample Type||Average % Recovery||Range %|
|Cell Culture Media (n=4)||103||94-108|
|Cell Lysis Buffer (n=1)||102||96-107|
|EDTA Plasma (n=4)||100||93-105|
|Heparin Plasma (n=4)||97||92-100|
Preparation and Storage
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
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