Maurice Instruments
Capillary Electrophoresis Systems for Automated icIEF and CE-SDS Analysis
A Workhorse Capillary Electrophoresis System for Protein Purity, Identity, and Heterogeneity Analysis
The MauriceTM system enables protein charge and size analysis on the same platform. Its simple plug-and-play design lets you switch between icIEF and CE-SDS assays with ease. Just pop in one of the preassembled cartridges, drop in your sample vials or a 96-well plate, and hit start. You'll complete your method development in a day and get high-resolution, reproducible data in minutes. Get compliant data with either Compass for iCE, Waters™ Empower® CDS, or Thermo Scientifc™ Chromeleon® CDS.
How can Maurice Instruments help you?
Get high-quality data to simplify decision-making
The Maurice system maintains peak resolution throughout the run because of whole-column imaging. High-quality data are generated, giving you insights into your molecule and guiding your next steps.
Get consistent results with thoughtful automation
Pre-assembled, ready-to-use icIEF and CE-SDS cartridges fully automate conditioning, sample injection, and system cleanup, thereby decreasing the chances of variability in results.
The optional On-Board Mixing (OBM) feature automatically mixes reagents with samples right before the run, thus preserving sample stability. This is a very useful feature for ADC (antibody drug conjugates) analysis.
Explore the Maurice Capillary Electrophoresis System
Explore the Maurice Capillary Electrophoresis System
From sample prep to data analysis, take a virtual tour and explore iCIEF and CE-SDS workflows on Maurice.
Instrument Specifications
| Feature | cIEF Specifications Maurice, Maurice C. | CE-SDS Specification Maurice, Maurice S. |
| Minimum Sample Volume | 50 µL | 50 µL |
| Sample Delivery | Vacuum | Electrokinetic |
| Typical Separation Time | 6–10 min (molecule-dependent) | Reduced IgG: 25 min, Non-reduced IgG: 35 min (CE-SDS PLUS) Reduced IgG: 5.5 min, Non-reduced IgG: 8 min (Turbo CE-SDS)
|
| Detection Capability | UV Absorbance at 280 nm Fluorescence: Ex 280 nm, Em 320– 450 nm | UV Absorbance at 220 nm |
| Typical Voltage | Pre-focusing: 1500 V, focusing: 3000 V | Separation: 5750 V |
| Sample Injections per Cartridge | 200 maximum | 200 maximum for CE-SDS, 500 maximum for CE-SDS PLUS |
| Maximum Sample Injections per Batch | 100 | 48 |
| pI/Size Range | 2.85–10.45 | 10–270 kDa |
| pI/Sizing CV | 0.01 | ≤2% |
| CV for Peaks >10% Composition | ≤5% (Intra-batch), ≤6% (Inter-batch) | N/A |
| Relative Migration Time CV | N/A | <1% for reduced IgG |
| pI/Sizing Resolution | 0.05 pI units (for wide range 3–10 ampholytes) | ≥1.5 for NGHC/HC IgG Standard |
| Dynamic Range | 2 logs | 2 logs |
| Linearity | >0.995 | >0.995 |
| Sensitivity (LOD) | 0.7 µg/mL (Native fluorescence) 3.0 µg / mL(Absorbance) (Values based on a monoclonal antibody) | 0.3 µg/mL (Value based on Internal Standard) |
| Sample Tray Options | 96-well plates or 48 vials | |
| Dimensions | 44cm H x 42cm W x 61cm D | |
| Weight | 46 kg (100 lb) | |
Compatible Products
| Charge Analysis | CE-SDS Analysis | ||
| Product | Catalog Number | Product | Catalog Number |
| Maurice System | 090-000 | Maurice System | 090-000 |
| Maurice C. System | 090-002 | Maurice S. System | 090-001 |
| Maurice cIEF Cartridge | PS-MC02-C | Maurice CE-SDS PLUS Cartridge | PS-MC02-SP |
| Maurice icIEF 400 Cartridge | PS-MC02-400C | Maurice Turbo CE-SDS Cartridge | PS-MC02-TS |
| Maurice cIEF Method Development Kit | PS-MDK01-C | Maurice CE-SDS PLUS Application Kit | PS-MAK03-S |
| Maurice Turbo CE-SDS Application Kit | PS-MAK01-TS | ||
Hear from Siddharth Sapa, Teva Pharmaceuticals, describe the benefits of using the Maurice system and the icIEF 400 cartridge, including high-throughput and ease-of-use.
How are scientists in the biopharmaceutical industry using the Maurice system for protein charge and size analysis? Check out these videos featuring scientists who have used Maurice for method transfer, formulation, and gene therapy development. They share their experiences and insights on using Maurice for different applications to do cutting-edge biotherapeutic development.
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