Bad [p Ser99] Antibody (679431) [PE]

Name: Bad [p Ser99] Antibody (679431) [PE]
Brand: Novus Biologicals
SKU: FAB7764P
Price: 499 USD
Availability: InStock

Novus Biologicals | Catalog # FAB7764P

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Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry

Label

PE (Excitation = 488 nm, Emission = 575 nm)

Antibody Source

Monoclonal Mouse IgG₁ Clone # 679431

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Product Specifications

Immunogen

Phosphopeptide containing the human Bad S99 site
Accession # Q92934

Modification

p Ser99

Specificity

Detects human Bad when phosphorylated at S99 in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁

Applications for Bad [p Ser99] Antibody (679431) [PE]

Application

Recommended Usage

Immunocytochemistry

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Bad

Bad is a pro-apoptotic member of the Bcl-2 family. Bad will bind preferentially Bcl-xL over Bcl-2 through its partial (9-16 a.a) BH3 domain. Additionally, Bad can reverse the death repressor activity of Bcl-xL but not of Bcl-2. Upon dephosphorylation, activated Bad translocates to the mitochondria and displace Bcl-2 from tBid sequestration to initiate mitochondrial dysfunction. The switching on/off of its phosphorylation by growth/survival factors regulates Bad activity.

Long Name

Bcl-xL/Bcl-2 Associated Death Promoter

Alternate Names

BBC6, BCL2L8

Gene Symbol

BAD

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Product Documents for Bad [p Ser99] Antibody (679431) [PE]

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Product Specific Notices for Bad [p Ser99] Antibody (679431) [PE]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.